Torsades de Pointes on Chronic Methadone Use

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Methadone-induced Torsades de pointes.

Torsades de pointes is a polymorphic ventricular tachycardia that can quickly evolve into ventricular fibrillation and sudden death. This arrhythmia often occurs secondary to medication- induced cardiac repolarization dysfunction with resultant prolonged QTc interval on ECG. Numerous medications can predispose patients to this deadly tachycardia. We report a case of methadone-induced Torsades d...

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[Torsades de pointes during methadone treatment].

Methadone is a synthetic opioid that has been used successfully to treat heroin addiction and chronic pain. It is usually well tolerated and has few side effects. Recently, an association with torsade de pointes has been reported. We present 4 cases of torsade de pointes during methadone treatment.

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Torsades de Pointes During Methadone Treatment

Four patients (3 men, 1 woman) with no known history of heart disease were seen in the emergency room for syncopal episodes (Table). All were under longterm methadone therapy, although only 1 was receiving >200 mg/day. Three of these patients were infected with human immunodeficiency virus (HIV), but only 1 was on antiretroviral therapy. The electrocardiographic recordings and monitoring showed...

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Methadone-induced torsades de pointes: a twist of fate.

A case of methadone-induced torsades de pointes is presented to demonstrate clinical features that predispose patients to this serious cardiac arrhythmia. A patient who was receiving methadone maintenance treatment for heroin addiction presented to the hospital with dizziness and near-syncope. He was taking a relatively high dose of methadone but was not taking any concomitant cytochrome P450 i...

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Torsades de Pointes (TdP) after Taking Prenylamine

L'intervalle de temps variable existante entre le debut du traitement par la prenylamine et la sur­venu de toisade de pointe et d'autre oart la raretee de· telle camplication est considere par les auteurs c0mme une indice de !'intervention de d'autres fac­teurs, parmie Jes quelles, la perturbation electroly­tique doit jouer le role principal. 

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ژورنال

عنوان ژورنال: International Journal of High Risk Behaviors and Addiction

سال: 2018

ISSN: 2251-8711,2251-872X

DOI: 10.5812/ijhrba.67762